Literature Study: Cortisol Hormone to DHEA-S Ratio as an Indicator of HPA Axis Activity in Chronic Stress and Insulin Resistance
), Febry Yeni Gultom(2), Judika Adventist Maleakhi Sihite(3), Naomi Putri Chelsea Solin(4), Melva Silitonga(5),
(1) Universitas Negeri Medan
(2) Universitas Negeri Medan
(3) Universitas Negeri Medan
(4) Universitas Negeri Medan
(5) Universitas Negeri Medan
Corresponding Author
Abstract
Chronic stress can disrupt the regulation of the Hypothalamic-Pituitary-Adrenal (HPA) axis, causing dysregulation of cortisol secretion and an imbalance in the ratio of cortisol to dehydroepiandrosterone sulfate (DHEA-S), which is implicated in the development of insulin resistance and Type 2 Diabetes Mellitus (T2DM). Cortisol, as an insulin antagonist, increases hepatic glucose production and reduces peripheral glucose uptake, while DHEA-S has a protective effect on glucose metabolism. This literature review aims to evaluate the evidence related to the role of the cortisol/DHEA-S ratio as a potential biomarker in the relationship between chronic stress and insulin resistance. The method used is a critical synthesis of previous studies on the mechanism of the HPA axis, the impact of stress on glucose metabolism, and the clinical significance of the cortisol/DHEA-S ratio. The results of the analysis indicate that an imbalance in the cortisol/DHEA-S ratio due to chronic stress contributes to impaired insulin sensitivity, reinforcing the importance of this biomarker approach in the management of T2DM risk. This study highlights the need for further research to validate the use of the cortisol/DHEA-S ratio as a predictive tool and therapeutic intervention.
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References
Ahmad, I., Jena, I., & Priyadarshi, A. (2023). Mathematical Modelling of Hypothalamus-Pituitary-Adrenal Axis Dynamics: A Review, a Novel Approach, and Future. arXiv preprint arXiv:2311.04570.
Aisyah, R. P., & Wahyono, B. (2021). Mutu Pelayanan Kesehatan Setelah Persalinan Yang Berhubungan Dengan Kepuasan Pelayanan Ibu Nifas. Indonesian Journal of Public Health and Nutrition, 1(2), 282-290.
Azzahra, D. A., Kurniawati, S. P., Octavianingrum, J. R., & Arini, L. D. D. (2025). Peran Hormon Kortikosteroid dalam Regulasi Metabolisme dan Respons Stres pada Manusia. Nian Tana Sikka: Jurnal ilmiah Mahasiswa, 3(2), 07-13.
Fitri, A. (2020). Hubungan Tingkat Stres Dengan Kadar Gula Darah Pada Polisi Yang Mengalami Gizi Lebih di Polresta Sidenreng Rappang (Doctoral dissertation, Universitas Hasanuddin).
Johnson, C., Taranets, R. M., Vasylyeva, N., & Chugunova, M. (2021). Existence and Stability Analysis of Solutions for an Ultradian Glucocorticoid Rhythmicity and Acute Stress Model. In Contemporary Approaches and Methods in Fundamental Mathematics and Mechanics (pp. 165-194).
Joseph, J. J., & Golden, S. H. (2017). Cortisol dysregulation: the bidirectional link between stress, depression, and type 2 diabetes mellitus. Annals of the New York Academy of Sciences, 1391(1), 20-34.
Noushad, S., Ahmed, S., Ansari, B., Mustafa, U. H., Saleem, Y., & Hazrat, H. (2021). Physiological biomarkers of chronic stress: A systematic review. International journal of health sciences, 15(5), 46.
Nuralita, N. S. (2023). Hubungan Efek Metabolik dan Hormon Kortisol Terhadap Pasien Gangguan Ansietas yang Berobat di Poli Psikiatri RS Madani Medan. Majalah Kedokteran Andalas, 46(6), 886-893.
Yuliadi, I. (2021). HPA Aksis dan Gangguan Psikosomatik HPA Aksis and Psychosomatic disorder. Jurnal Ilmiah Psikologi Candrajiwa, 6(1), 1-22.
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DOI: 10.57235/arrumman.v2i1.6010
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Copyright (c) 2025 Odor Debora Pita Uli Sinaga, Febry Yeni Gultom, Judika Adventist Maleakhi Sihite, Naomi Putri Chelsea Solin, Melva Silitonga
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